Monday, 5 November 2018

Dogs Can Detect Malaria. How Useful Is That?

Dogs Can Detect Malaria
Dogs have such exquisitely sensitive noses that they will detect bombs, drugs, citrus, and other contraband in luggage or pockets.

Is it possible that they will scent out even malaria? And when might that be useful? A small pilot study has shown that dogs can accurately identify socks worn overnight by children infected with malaria parasites — even when the youngsters had cases so mild that they were not feverish.

The study, a collaboration between British and Gambian scientists and therefore the British charity Medical Detection Dogs was released last week at the annual convention of the American Society of Tropical Medicine and Hygiene.

In itself, such canine prowess is not surprising. Since 2004, dogs have shown that they can detect bladder cancer in urine samples, lung cancer in breath samples, and ovarian cancer in blood samples.

Trained dogs now warn owners with diabetes when their blood glucose has dropped dangerously low and owners with epilepsy once they are on the verge of a seizure.

Other dogs are being taught to detect Parkinson’s disease years before symptoms appear.

The new study, its authors said, doesn't mean that dogs will replace laboratories.

Inexpensive rapid tests for malaria have been available for over a decade; more than 200 million people in dozens of countries are infected each year.

But for sorting through crowds, malaria-sniffing dogs could potentially be very useful.

Some countries and regions that have eliminated the disease share heavily trafficked borders with others that have not.

For example, South Africa, Sri Lanka, and the island of Zanzibar have no cases but get streams of visitors from Mozambique, India, and mainland Tanzania.

And when a neighborhood is on the brink of eliminating malaria, dogs could breeze through villages, nosing out silent carriers — people that aren't ill but have parasites in their blood that mosquitoes could pass on to others.

Dog noses are 10,000 to 100,000 times as sensitive as human noses.

Scientists aren't sure exactly what dogs are smelling, but it's known that malaria parasites produce volatile aldehydes like those found in perfumes.

The parasites may have evolved the power to exude odoriferous chemicals so as to draw in mosquitoes to hold them to new hosts.

Studies have shown that mosquitoes like better to bite people that have malaria.

If just one chemical indicated cancer or malaria, “we’d have discovered it by now,” said Claire Guest, who founded Medical Detection Dogs in 2008 and oversaw dog training in the study.

“It’s more sort of a tune of the many notes, and therefore the dogs can pick it up.”

Most breeds have good noses, she said, but the simplest for this task are dogs bred to hunt — like pointers, spaniels and Labradors — and dogs with relaxed relationships with their owners.

The initial trials were just to prove that detection was feasible, said Steve W. Lindsay, an entomologist at Durham University in Britain who said he was inspired by a dog sniffing luggage for contraband food at Washington Dulles airport.

This the preliminary study involved training just two dogs to smell rows of jars containing bits of thin nylon socks that had been worn overnight by Gambian children.

When the dogs, a Labrador-golden retriever mix named Lexi and a Labrador named Sally, recognized the telltale odors, they were alleged to stop and point at the jar.

They were only about 70 percent accurate at spotting socks from children with malaria, but 90 percent accurate at not giving false positives.

Their accuracy may need been higher under different circumstances, Dr. Lindsay said.

Some children had probably shared beds with infected siblings, and therefore the socks had to be stored during a freezer for a year while the dogs were trained and the study design approved.

“W.C. Fields said, ‘Never work with children or animals,’ and here we are working with both,” he said.

Because some Muslims avoid dogs or their saliva as unclean, Dr. Lindsay worried that African Muslims — of which there are millions — would object to being sniffed.

But the Quran permits dogs used for hunting or guarding homes, and after discussing the difficulty with Gambian imams, he brought dogs wearing red “Medical Detection” jackets into villages.

“Once we explained what we were doing, people were quite O.K. with it,” he said.

He was asked if smaller, cheaper, or more local animals might be trained — African giant pouched rats, for instance, are wont to detect land mines and tuberculosis.

“Yes, I suppose,” he said. “But at ports of entry, I feel people would rather see dogs running around than rats.

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